How SAM-e works on Arthritis:

S-adenosyl-methionine exists naturally in almost all the fluids and tissues of the human body. Sam-E participates in different biochemical reactions inside the human body by donating methyl moleculs. In some biochemical process, methyl molecules are needed to produce the chemical compounds that are necessary for controlling pain, inflammation and cartillage repair. Studies done by Mayo Clinic in 2002 ( “Alternative Arthritis Treatments” ) shows that Sam-E provides the same pain relieving action as Ibuprofen but with fewer side effects. Another benifit from SAM-e supplementation is its ability to fight depression by increasing the levesl of serotonin inside the brain.’

Side Effects and Precautions of SAM-e:

There are no reported interactions with other supplements or medications. Higher intake levels of SAM-e may lead to an increase in homocysteine which contributes to heart disease. To avoid conversion of SAM-e into homocysteine, take Vitamin B6@50mg, B12@1000mcg and Folic Acid@800mcg.

Forms, Dosage and Brand Names of SAM-e:

Adults: For joint health take 2 tablets a day (400mg) preferably on empty stomach 1 hour away from food. Increase the dosage up to 800mg as needed. Since SAM-e is unstable at high temperatures, it is best to keep this food supplement refrigerated.

Pregnant Women: Not recommended.

Children: Not recommended.

References about SAM-e and Arthritis:

Gutierrez S, et al. SAMe restores the changes in the proliferation and in the synthesis of fibronectin and proteoglycans induced by tumor necrosis factor alpha on cultured rabbit synovial cells. Brit Rheumatol 37: 27-31, 1997

Mansell JP, et al. Biochemical eveidence for altered subchondral bone collagen metabolism in osteoarthritis of the hip. Brit J Rheumatol 36:16-19, 1197

Osteoarthritis: the clinical picture, pathogenesis and management with studies on a new therapeutic agent, S-adenosylmethionine. Am J Med 83 (Suppl 5A) 1987 (Includes Numerous Studies).

Marcolongo R, et al. Double-blind multicentre study of activity of S-adenosylmethionine in hip and knee osteoarthritis. Curr Ther Res 37: 82-94

Tavoni A. et al Evaluation of S-adenosylmethionine in primary fibromyaglia: a double blind crossover study. Am J Med 83 (Suppl 5A): 107-110, 1987

Jacobsen S, et al Oral S-adenosylmethionine in primary fibroyaglia. Double-blind clinical evaluation. Scand J Rheumatol 20: 294-302, 1991

Fassbender HG, Role of chondrocytes in the development of osteoarthritis. Am J Med 83 (Suppl 5A):17-24, 1987

Page last updated: May 02, 2009