How Glucosamine works on arthritis:

Glucosamine sulfate exists around the cartilage cels naturally. Chemically, glucosamine is an amino sugar which the body produces and then  carries it to connective tissues. The human body can produce the amount of glucosamine necessary for the maintennance of healthy joints. As the body ages,  it also  loses its ability to  generate enough glucosamine  to keep the joints in very good health. Research shows that supplementation of glucosamine may slow down the progression rate of arthritis by helping the joint cartilage healthy. Glucosamine also helps in easing the pain caused by osteoarthritis, rehabilitation of cartilage, joint repair, stimulation of proteoglycans and glycosaminoglycans, and renewal of synovial fluid.

Side Effects and Precautions of Glucosamine:

Glucosamine is fairly safe and does not carry the worrying side effects of NSAIDs. Some people may experience stomach cramps or loose stools.

Forms, Dosage and Brand Names of Glucosamine:

Adults: 1,500 mg a day given as 500 mg tablets or capsules three times a day.

Pregnant Women: It is best not to take glucosamine until more is known about the effects of this supplement.

Children: Not recommended

References about Glucosamine and Arthritis:

Reginster JY, Gillot V, Bruyere O, Henrotin Y. Evidence of nutriceutical effectiveness in the treatment of osteoarthritis. Curr Rheumatol Rep 2000; 2: 472-77.

Constantz RB. Hyaluronan, glucosamine and chondroitin sulfate: roles for therapy in arthritis? In: Kelley WN, Harris ED, Ruddy S, Sledge CB, eds. Textbook of rheumatology. Philadelphia: WB Saunders, 1998.

Deal CL, Moskowitz RW. Nutraceuticals as therapeutic agents in osteoarthritis: the role of glucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin North Am 1999; 25: 379-95.

McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA 2000; 283: 1469-75.

Page last updated: May 02, 2009